Jaffe have suggested that HL-like ALK negative ALCL should be diagnosed only when tumor cell morphology closely resemble Hodgkin’s lymphoma but immunohistochemical study show characteristics of ALCL (positive staining for CD30, EMA, CD3 but negative for EBV and B-cell markers) [24]. The gene discussed is TNFRSF8; the disease is Hodgkins lymphoma.