In the present case, besides ALK and CD30 expression, the neoplastic cells were also positive for T lymphocyte lineage markers as CD5, TIA-1, and Granzyme B, while negative for CD20, CD79a, CD38, CD138, suggesting the T-cell origin of these cells and the diagnosis of ALK positive ALCL. The gene discussed is GZMB; the disease is anaplastic large cell lymphoma.