Differences between the effects achieved by silencing AKT3 (in a setting of miR122 absence) and miR122 reestablishment, define the key facts in tumor cell dormancy: increase in functional p38 and cell cycle progression inhibitors p21 and p15, modulation of IGF1/IGF1R signaling pathway which, in turn, regulates AKT2 activation and subsequent FOXO activity. Here, CDKN2B is linked to neoplasm.