ESR1 and neoplasm: The genes whose expression correlates with that of EPRS in TCGA and METABRIC ER+ tumor samples are significantly enriched for predictors of nonresponse to tamoxifen therapy [13–15] (TCGA: corrected FET p = 3.96-16, FE = 3.78; METABRIC: corrected FET p = 2.52-06, FE = 3.08) (Figure 2B).