We found elevated EPRS expression to be associated with poorer overall survival in patients with ER+ breast cancers in both TCGA (KM p = 5.29e-03, Cox p = 1.04e-03; HR = 2.07) and METABRIC datasets (KM p = 7.73e-03, Cox p = 1.67E-02; HR = 1.23) (Figure 1E). This evidence concerns the gene ESR1 and breast cancer.