Thus, additional evidence like Cenani-Lenz syndactylyl syndrome or fibrochondrogenesis-1 and the association between the index SNP in LRP4 and LRP4 transcript abundance strongly support that the genes identified using GenToS may be the causal one or represent an additional phenotype-associated gene in an associated locus (Table 1). This evidence concerns the gene LRP4 and fibrochondrogenesis.