F2R and type 2 diabetes mellitus: However, we found that PAR1 or PAR4 stimulation induced similar platelet releases of angiogenic regulators in both control and T2DM subjects, and that angiogenic activities of platelets from mild T2DM patients were not changed either, as supplementation of either platelet releasates or washed platelets from non-diabetic and diabetic subjects enhanced ECFC tube formation similarly.