When capillary-like tubular structures of ECFCs were quantified using WimTube tube formation image analysis, it was found that PAR1-PRs from both non-diabetic controls and T2DM patients similarly increased the total branch points (H) and total tube length (I) of ECFC tube formation, as compared to those obtained without supplementation of platelet releasates. The gene discussed is F2R; the disease is type 2 diabetes mellitus.