DPH3 and cancer: By expanding our analysis to cancer sets outside of the TCGA to include exome data from basal cell carcinoma samples and Merkel Cell Carcinoma cell lines, we demonstrated that many of these hotspot mutations are found in other UV-related cutaneous malignancies; consistent with this observation, a recent study evaluating DPH3 promoter mutations in non-melanoma skin cancer found a high frequency in both BCC and squamous cell carcinoma [34].