Considering the confirmed role of ZIP4 in the carcinogenesis of pancreatic, liver cancer, and glioblastoma multiform (GBM) [22, 23, 28–30], we further conducted a similar investigation with expanded samples of 36 paired specimens of tumor and surrounding benign tissues from a separate cohorts of patients who had non-small cell lung cancer. The gene discussed is SLC39A4; the disease is liver cancer.