Also, a large proportion of human bladder tumors show alterations in some of the phosphatidylinositol 3-kinase (PI3K) pathway components; in particular, the phosphatidylinositol 3-kinase catalytic subunit alpha (PIK3CA) gene [10] that is involved in controlling cell growth, survival, and proliferation and has been considered a promising target for cancer therapy [11, 12]. Here, PIK3CA is linked to cancer.