Consistently, SR48692, TWS119, and DKK-1 significantly inhibited tumor invasion, in which the cell counts in the Transwell invasion assay declined from 63.33 ± 1.52/104 cells to 32.67 ± 2.51/104 cells, 28.33 ± 1.21/104 cells, and 29.67 ± 5.03/104 cells, respectively (P < 0.001; Figure 6f). This evidence concerns the gene DKK1 and neoplasm.