LDHA and acute myeloid leukemia: In the particular case of AML, the ALDH gene family is found upregulated or amplificated in 42% of cases, impacting also life expectancy, negatively (Supplementary Figures 2A and B).22, 23 These data suggest that the altered ALDH activity in AML confers advantages for cell proliferation and survival and/or for the progression of the disease.