Indeed, DIMATE induces an irreversible apoptosis in human prostate epithelial cancer cells DU145, but it is a reversible cytostatic agent on human prostate epithelial normal cells.18, 19 In the specific AML framework, safety of ALDH inhibitor on healthy HSCs has already been demonstrated, and even more remarkable is the inhibition of ALDH and retinoid signaling induces expansion of human HSCs.24 The gene discussed is LDHA; the disease is acute myeloid leukemia.