Garding et al.21 provided insights into the epigenetic mechanisms regulating the expression of the DLEU1 and DLEU2 genes, mapped to the critical region at chromosomal band 13q14.3 which is deleted in over 50% of patients with CLL.9, 22 DLEU2 hosts the miR-15a/16-1 cluster, known for its crucial role in CLL pathogenesis.23 The only additional evidence of the involvement of lncRNAs in CLL suggest a role for NEAT1 and lincRNA-p21 as novel elements of the p53-dependent DNA damage response machinery.24 This evidence concerns the gene TP53 and B-cell chronic lymphocytic leukemia.