MiR-574-3p is upregulated in UM-CLL and is associated with a major risk of disease progression in the same cohort of CLL.31 Considering that miR-574-3p has been described as a tumor suppressor miRNA in different types of solid tumors,45 we can hypothesize that in CLL, lnc-LINS-1 may play a fine-tuning role in the regulatory circuitry including miR-574-3p and its target genes. This evidence concerns the gene LINS1 and B-cell chronic lymphocytic leukemia.