Again, among the seven lncRNAs differentially expressed, NOTCH1 mutated CLLs showed an upregulation of lnc-IRF2-3, lnc-AC004696.1-1 and lnc-BACH1-1, and a downregulation of lnc-C1orf132-1, all of which were found to be deregulated in CLL subgroups with adverse prognostic factors. This evidence concerns the gene NOTCH1 and B-cell chronic lymphocytic leukemia.