Recently, works from our group have shown that circulating ZAG levels are lower in patients with nT2DM and correlated positively with ADI and inversely with body mass index (BMI), waist-to-hip ratio (WHR), and homeostasis model assessment of insulin resistance (HOMA-IR), further suggesting that ZAG may be an adipokine associated with insulin resistance (IR)6. This evidence concerns the gene AZGP1 and Insulin resistance.