Collectively, our results demonstrate that 12 wks of DAPA treatment decreases HbA1c, FBG, 2hPBG, FFA, TG, WHR, body weight, FAT%, and plasma FFA levels, reduces the HOMA-IR and circulating TNFα levels, and increases circulating ADI and ZAG concentration in T2DM patients. This evidence concerns the gene TNF and type 2 diabetes mellitus.