AKT1 and hepatocellular carcinoma: Inhibition of both PI3K/mTORC1/2 (NVP-BEZ235) (Fig 7A and 7D) and AKT (MK-2206) (Fig 7B and 7E) blocked heat stress induced phosphorylation of AKT at Ser473 and Thr308 and significantly decreased HCC clonogenic survival to sublethal heat stress [58, 63].