Moreover, HCC tumors with a poor prognostic cluster A (p<0.0001; Fig 8E), hepatic stem cell (HS) subtype (p<0.01; Fig 8F), higher tumor grade (p<0.03; Fig 8G), vascular invasion (p<0.05; Fig 8H) and metastasis (p<0.01; Fig 8I) had significantly greater expression of AKT3. Here, AKT3 is linked to hepatocellular carcinoma.