PTPA and Lewy body dementia: Furthermore, αSyn positively regulates PP2A under normal physiological conditions, especially when αSyn is dephosphorylated [14, 16], and Lewy-body-like αSyn aggregation causes loss of PP2A activity in adrenals of aging synucleinopathy mice as well as in brain from patients with Dementia with Lewy bodies (DLB) or PD [15, 20].