The higher expression ratio between PD patients and controls substantia nigra whole tissue was observed in chromosome 1 [coordinates 22,250,001–22,750,000], with three known genes of the human complement subcomponent C1q showing values within the higher 2.5th percentile: C1QA and C1QB and C1QC. Then TRAM analysis retrieved a segment on chromosome 7 [spanned from coordinates 23,250,001–23,750,000], containing two sequences referred to EST clusters, Hs.644466 and Hs.743502 and the FAM221A gene, encodes for a protein with unknown function. This evidence concerns the gene FAM221A and Parkinson disease.