IL10RA and viral infectious disease: Strikingly, the clinical score at 22 dpi was significantly increased in TMEV-infected mice (group “IL-10R↓early/TMEV”) compared to mock-infected animals (group “IL-10R↓early/mock”) following anti-IL-10R Ab treatment, suggestive of a triggering or additive effect of acute virus infection upon IL-10R deficiency-mediated systemic signs (Fig 3, Table B in S1 File).