Down-regulated Dicer expression has been shown in HCC [20], lung cancer [12], ovarian cancer [21], nasopharyngeal cancers [22], breast cancer [23], and esophageal cancer [24], whereas up-regulated Dicer expression was identified in lung adenocarcinoma [13], colorectal cancer [25], and primary cutaneous T-cell lymphomas [26]. The gene discussed is DICER1; the disease is lung cancer.