We measured the levels of ROS and DJ-1 in the sera from 85 patients with SM, including ISM, the most common and the least severe variant of SM, smoldering systemic mastocytosis (SSM) which is a variant that shows indications of slow progression and over time results in a high burden of neoplastic cells [28], and aggressive SM (ASM), a variant that can be life threatening [28–30]. Here, PARK7 is linked to aggressive systemic mastocytosis.