TNF-α and IL-1β are extremely important in the induction of arthritis, can trigger the production of matrix metalloproteinases (MMPs), and ultimately damage the synovial and articular cartilage35, In addition, macrophages and FLSs can produce proinflammatory cytokines such as TNF-α, IL-1β, IL-6, IL-8. Here, TNF is linked to Arthritis.