The high nuclear expression of GS28 was also strongly associated with worse OS (mean OS, 91.7 vs. 105.5 months; log-rank test, P = 0.025) in patients without lymph node metastasis at the time of the surgery (Fig 2E) but it was not associated with PFS (mean PFS, 93.2 vs. 105.1 months; log-rank test, P = 0.132) (Fig 2F) in this group. The gene discussed is GOSR1; the disease is metastatic malignant neoplasm in the lymph nodes.