Hence, multivariate analysis revealed that high nuclear expression of GS28 is an independent prognostic factor of OS (hazard ratio = 3.969, P = 0.019) for patients without lymph node metastasis but not for patients with lymph node metastasis (P = 0.298) (Table 5). Here, GOSR1 is linked to metastatic malignant neoplasm in the lymph nodes.