CSF3 and Stroke: Animal data is based on models of large artery occlusion, as seen clinically in cortical infarction–there is no experimental data in lacunar stroke or small vessel disease.[41] However, the only clinical study of G-CSF in chronic stroke was performed in elderly patients with white matter disease.[19] When this study was developed in conjunction with stroke survivors, they strongly argued for broad inclusion criteria, to make the study more accessible and the results generalizable.