Animal data is based on models of large artery occlusion, as seen clinically in cortical infarction–there is no experimental data in lacunar stroke or small vessel disease.[41] However, the only clinical study of G-CSF in chronic stroke was performed in elderly patients with white matter disease.[19] When this study was developed in conjunction with stroke survivors, they strongly argued for broad inclusion criteria, to make the study more accessible and the results generalizable. This evidence concerns the gene CSF3 and stroke disorder.