Via mediating β1 integrin subunit and ERK activation in human dermal lymphatic endothelial cells (HDLEC), junctional adhesion molecule-C (JAM-C) contributes to lymphangiogenesis and nodal metastasis, suggesting that JAM-C may be a target for treating lymphatic metastases in NSCLC [45]. Here, JAM3 is linked to non-small cell lung carcinoma.