Loss of SH3GL2 is frequently detected in NSCLC and SH3GL2 can mediate cellular growth and invasion through interacting with EGFR [40]. CDX2, VIL1, and BAI3 levels have significant differences in SCLC and large-cell neuroendocrine lung carcinoma (LCNEC); therefore, they can be diagnostic markers of these tumor types [41]. This evidence concerns the gene ADGRB3 and pulmonary large cell neuroendocrine carcinoma.