Therefore, the association between persistent presence of LA and clinical symptoms of APS is well established compared with other test items that has been in conflict [15–21] and, in this study, the clinical symptom positivity rates among patients with persistent positivity in LA tests were 50.0% (1/2), which was higher than that of 23.1% (3/13) and 30.8% (4/13) in anti-β2GPI antibody test and ACA test, respectively. The gene discussed is APOH; the disease is autoimmune polyendocrinopathy.