SPARCL1 and lung cancer: Also some genes are relevant to cancers but lung cancer from literature study (COL5A2 [51], SPARCL1 [35], EFEMP2 [39], MSR1 [49], and DOCK2 [61]). APARCL1 and DOCK2 have shown downregulation in types of cancer [36, 61], while both of them show downregulated gene expressions in T-DM with high occurrences of DNA hypermethylation.