All these genes obtain higher occurrences (n > 19) in lung adenocarcinoma. AGR2, CDH13, CRYAB, MX2, SH100P, and SH3GL2 are reported with aberrant gene expression [38, 40, 47, 54, 58, 59], while AGR2, CDH13, and MX2 are of high occurrences in aberrant DNA methylation (n ≥ 18). The gene discussed is CRYAB; the disease is lung adenocarcinoma.