EFEMP2 and central nervous system cancer: Similar to CRYAB, EFEMP2 shows contrary expression patterns in our observation compared to which in gliomas [39]. EFEMP2 has high occurrences of DNA hypermethylation and downregulated gene expression in totally 20 samples, while 2 samples in T-NDM show little differences when compared to matched normal. COL5A2 also shows T-DM specific upregulation of gene expression and DNA hypermethylation with high occurrences.