PROM1 and hepatocellular carcinoma: Lin et al. [22] found that ursolic acid chalcone (UAC) generated a decrease in self-renewal capability and an increase in sensitivity to doxorubicin and vincristine drugs to inhibit the expression of CD133+ in a dose- and time-dependent manner in PLC/PRF/5 and Huh7 HCC cells, which could be a potent therapeutic agent to target differentiation of CSC in HCC.