PROM1 and hepatocellular carcinoma: Compared with CD133+EpCAM−, CD133−EpCAM+, and CD133−EpCAM− counterparts, CD133+EpCAM+ cells possessed more representatives for TICs in HCC Huh7 cells, such as abundance in side population cells, increased colony-formation ability, higher differentiation capacity, drug resistance to some chemotherapeutics, preferential expression of stem cell-related genes, more spheroid formation of culture cells, and stronger tumorigenicity in NOD/SCID mice [80].