Here, we sought to evaluate (a) the mRNA expression of ERBB1–4 in pretreatment tumor tissue, (b) the correlation of expression of each receptor along with tumor cell proliferation using MKI67 mRNA expression in patients with LARC treated with 5-FU-based chemoradiotherapy, and (c) the impact of these markers on prognosis. Here, EGFR is linked to neoplasm.