Zika Virus infection of human fibroblasts also resulted in upregulation of RIG-I and MDA5, what might be associated to the observed production of IFN-α and IFN-β, increased expression of IRF7 and upregulation of IFN stimulated genes (ISG), such as OAS and ISG15 (Hamel et al., 2015). Here, IFIH1 is linked to Zika virus infectious disease.