The main findings of the present single center study were as follows: (1) patients with hypertension either with or without prediabetes appeared to benefit from treatment with single-pill combination of amlodipine 5 mg and atorvastatin calcium 10 mg, as reflected by significant reductions in ICAM-1 and TNF-α levels; and (2) said reductions in ICAM-1 and TNF-α levels were more pronounced in hypertensives with than without prediabetes, and independent of BP or cholesterol level reductions. This evidence concerns the gene TNF and prediabetes syndrome.