TNF and prediabetes syndrome: While the population in the present study was at lower risk (only age >45 years, hypertension or smoking as risk factors), short-term treatment of hypertensives with or without prediabetes with amlodipine plus atorvastatin calcium was enough to reduce ICAM-1 and TNF-α levels, with the effect being more pronounced in the presence of both conditions, indicating that use of this combination in such lower risk population can also improve endothelial function and inflammation.