While the population in the present study was at lower risk (only age >45 years, hypertension or smoking as risk factors), short-term treatment of hypertensives with or without prediabetes with amlodipine plus atorvastatin calcium was enough to reduce ICAM-1 and TNF-α levels, with the effect being more pronounced in the presence of both conditions, indicating that use of this combination in such lower risk population can also improve endothelial function and inflammation. The gene discussed is TNF; the disease is Hypertension.