Factors such as vascular health (e.g., hypertension), genetics (e.g., apolipoprotein E genotype), cognitive reserve, exercise and social interaction can all affect brain aging, both positively and negatively (Moffat et al., 2000; Raz et al., 2005; Stern, 2009; Hayes et al., 2014; Love et al., 2015), which can in turn affect functional activation and behavioral performance outcomes. Here, APOE is linked to hypertensive disorder.