FMR1 and epilepsy: Among the genes down-regulated in the En2−/− hippocampus the following terms were significantly enriched: epilepsy, asdM12 (a neuronal module enriched for ASD-associated genes; Voineagu et al., 2011), FMR1 interacting genes, dopaminergic markers, GABAergic postsynaptic markers and glutamatergic presynaptic markers; conversely, type I microglia markers were significantly enriched among BTBR down-regulated genes (Figures 5A,B).