TP53 and colorectal cancer: Eight per cent (4/48) polyps carried mutations in TP53. Ten per cent (5/48) had mutations in FBXW7, similar to the incidence in colorectal cancers.24 Seventeen per cent (8/48) of all polyps carried the BRAF p.V600E mutation; however, this was restricted to SSAs and HPs and found in the majority 80% (8/10) of these polyps.