TP53 and colorectal cancer: Considering that the functional effect of β-catenin expression maybe provides a survival advantage to colorectal cancer cells in oxaliplatin treatment, we developed p53+/+ HCT116 cells transiently transfecting the β-catenin plasmids or empty vector and examined whether β-catenin overexpression alters cell viability upon oxaliplatin treatment (20 μM, 24 h or 48 h).