In patients developing AKI 2/3 within the next 48 h, [TIMP-2]*[IGFBP7] increased significantly already on the 1st postoperative day (4.62 ± 3.14 (ng/ml)2/1000) followed by a decline to 3.40 ± 1.86 on postoperative day (POD) 2. This evidence concerns the gene TIMP2 and acute kidney injury.