No significant rise in urinary [TIMP-2]*[IGFBP7] urine concentration was observed in patients with KDIGO AKI 0/1 at any time with a maximum value on the 3th postoperative day of 1.75 ± 3.63 indicating that surgical intervention with TAVI per se has no influence on the investigated G1 cell cycle arrest biomarkers. The gene discussed is TIMP2; the disease is acute kidney injury.