[TIMP 2]*[IGFBP7] measured on day one after TAVI showed a sensitivity of 100 % and a specificity for predicting KDIGO AKI 2/3 (AUC 0.971, 95 % CI 0.914–1.000, SE 0.0299, p = 0.001, cut off 1.03). The gene discussed is IGFBP7; the disease is acute kidney injury.