IGFBP7 and acute kidney injury: At a cut-off of 0.91, the maximum value of [TIMP 2] *[IGFBP7] urine concentrations within 24 h after intervention showed a 87.5 % sensitivity and a 82.8 % specificity for detecting patients who develop KDIGO AKI 2/3 (AUC 0.869, SE 0.080, 95 % CI 0.721–1.0, p = 0.002).