Meersch et al. were able to show that the maximum [TIMP 2]*[IGFBP7] concentration within the first 24 h after cardiac surgery has a sensitivity of 0.92 and specificity of 0.81 at a cut-off value of 0.50 for the prediction of AKI, performing better than creatinine or NGAL [22] in 50 patients. Here, IGFBP7 is linked to acute kidney injury.