A knockdown (KD) of TG2 in breast cancer cells expressing high levels of TG2 reduced IL-6 expression, moreover, TG2 KD and IL-6 KD cells did not exhibit a stem-cell-like phenotype and were unable to form tumor spheres, grow in vivo, or metastasize at distant sites in xenograft models [17]. This evidence concerns the gene TGM2 and breast carcinoma.