IL-6 expression from IL-1β stimulated TG2-overexpressing MCF7_TG2 breast cancer cells was inhibited by an IRAK1/4 inhibitor, BAY11-7082 (a NF-kB inhibitor), SP600125 (a JNK inhibitor), and LY294002 (a PI3K inhibitor), but not by PD98059 (an ERK inhibitor) or SB209580 (a p38 mitogen-activated protein kinase inhibitor) (Fig. 5a). The gene discussed is MAPK8; the disease is breast cancer.