These studies have identified PCa susceptibility loci on chromosome 1, including hereditary PCa families (HPC), HPC1 (1q24–q25), PCAP (1q42–q43), HPCX (Xq27–q28), CAPB (1p36), HPC20 (20q13), HPC2/ELAC2 (17p11) and 16q23 [107, 108, 111]. The gene discussed is ELAC2; the disease is posterior cortical atrophy.