AKT1 and pancreatic neoplasm: In our clinical treatment, Radix Paeoniae Alba together with other herbs showed significant anti-cancer efficacy among patients with pancreatic cancer23, and in vitro experiments showed that the crude water extract of Radix Paeoniae Alba inhibited ErbB3 phosphorylation and retarded PI3K/Akt signaling in the pancreatic cancer cell lines BxPC-3 and L3.6pl (Figure S1).