In our clinical treatment, Radix Paeoniae Alba together with other herbs showed significant anticancer efficacy among patients with pancreatic cancer, and in vitro experiments showed that the crude water extract of Radix Paeoniae Alba inhibited ErbB3 phosphorylation and retarded PI3K/Akt signaling in pancreatic cancer cells. Here, ERBB3 is linked to familial pancreatic carcinoma.