Over-expressed ErbB3 protein is the preferred dimerization partner of EGFR and is involved in the erlotinib response in pancreatic cancer cells12, 13, 14, but it could also influence pancreatic cancer tumorigenesis, as high expression of ErbB3 correlates with advanced disease stage and decreased overall survival39, 40. Here, ERBB3 is linked to familial pancreatic carcinoma.