Because previous studies on AD have reported increased CRMP2 phosphorylation which may be related to amyloid burden [16, 17], we were interested in studying these associations in LBD, and compared the immunoreactivities of cytosolic phosphorylated CRMP2 between the two clinical subgroups known to manifest relatively high (DLB) and low (PDD) cortical Aβ [21–23]. This evidence concerns the gene DPYSL2 and Alzheimer disease.