An aberrant increase in lipogenesis and lipid accumulation in hepatocytes is a hallmark of metabolic syndrome, including NASH.2, 12, 13 It has been shown that MSP−/− mice develop hepatic steatosis with an accumulation of lipid droplets in hepatocytes under normal chow diet,20 indicating a key role of MSP in regulating hepatic lipid metabolism. The gene discussed is MST1; the disease is metabolic syndrome.