In this study, we investigated the effects of DISGT on atherosclerosis-related markers, including intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin, in high-fat diet (HFD)-induced apolipoprotein E-deficient (ApoE−/−) mice. This evidence concerns the gene APOE and atherosclerosis.