C-reactive protein (CRP), one of the acute-phase proteins in inflammation, is produced in response to increased circulating IL-6 and TNF-α, etc. [5] Although results from experimental studies indicated that CRP, IL-6 and TNF-α may be involved in the development of colorectal neoplasia [5–6], published data on circulating CRP, IL-6 and TNF-α and the risk of colorectal adenomas are not conclusive [8–37], respectively. This evidence concerns the gene IL6 and colorectal adenoma.