PHRF1 and neoplasm: Figure 4B showed that there was a significant decrease in the mean of tumor weight in the group of H1299-PHRF1 cells (0.35±0.21 g) as compared to that in the group of H1299-pvoid cells (1.29±0.36 g) (P < 0.05), which suggests that overexpression of PHRF1 significantly inhibited the tumor formation and tumor growth of H1299 cells in vivo.