TNFRSF10B and Miyoshi myopathy: One possibility for not observing cross-resistance between CPT and current anti-MM agents is that CPT primarily targets DR4 and DR5 to induce apoptosis through activation of the extrinsic apoptotic pathway, whereas these agents (e.g., bortezomib and IMiDs) act mostly via the mitochondria-mediated intrinsic apoptotic pathway.