Of note, most TRAEs were grade 1–2; grade 3–4 TRAEs were reported in 37.0% (10/27) of patients, including AST elevation (18.5%), leucopenia (11.1%), neutropenia (11.1%), ALT elevation (7.4%), thrombocytopenia (7.4%). This evidence concerns the gene GPT and Decreased total neutrophil count.