Now reported in 15 solid tumor types [75], this process was first described in uveal melanoma, the plasticity of cancer cells allows remodeling and acquisition of EC markers (such as CD31 and vascular endothelial (VE)-cadherin), and the formation of de novo vascular-like networks that may connect the tumor to the endothelial-lined vasculature [73]. The gene discussed is PECAM1; the disease is neoplasm.