FGF1 and neoplasm: In pancreatic cancer models, a VEGFR2 blocking antibody prevents tumor growth for approximately two weeks, however after this period tumors rapidly regrow and increase their vascularity with a concomitant increase in fibroblasts growth factor-1 (FGF-1), FGF-2, Ephrin-A1 (Eph-A1), Eph-A2 and angiopoietin-1 (Angpt-1) levels [24].