Recently, a small soluble decoy receptor fusion protein that comprises a truncated portion of the extracellular region of FGF Receptor-1 (named FGF-Trap) has demonstrated high affinity for FGF-2 and a potent inhibitory activity on the FGF signaling pathway, suppressing FGF-2 induced cell proliferation and significantly decreasing tumor growth and angiogenesis in vivo [34]. This evidence concerns the gene FGF2 and neoplasm.