lncRNAs can be direct targets of ER in luminal A-like breast cancer cells and can serve as predictive biomarkers [62].Furthermore, Miano et al. [63] have found 133 ERα-dependent lncRNAs that are highly specific for luminal-like breast cancer and are therefore very promising in defining this specific subtype of breast cancer. The gene discussed is ESR1; the disease is breast carcinoma.