Salunkhe et al. investigated whether modulation of the expression of various VGSC subunits could have an impact on insulin secretion, and found out that VGSCs, especially NaV1.3 (encoded by Scn3A), are regulated by microRNA-375 in rat insulinoma INS-1 832/13 cells and in primary mouse β cells [74]. Here, SCN3A is linked to pancreatic insulinoma.