Nrf2 acts as a sensor of oxidative stress and therefore plays an important role in redox homeostasis and in the protection of cells against toxic insults and pathogen-associated diseases.19 However, Nrf2 activation is frequently present in cancer, and pharmacological targeting of the Keap-1–Nrf2 system has been investigated as a therapeutic strategy.20 Despite the known protective effect of Nrf2, few studies have assessed its potential to improve stem cell therapy. The gene discussed is KEAP1; the disease is glycogen storage disease VI.