Senescence in brain microvascular ECs is closely related with stroke and vascular dementia.27 It has been reported that loss of CD47 protects neurons from both caspase-dependent and -independent apoptosis.28 In the present study, we found that TSP1-CD47 signaling inhibits EC proliferation and function, and induces EC replicative senescence. The gene discussed is CD47; the disease is vascular dementia.