TP53 and plasma cell myeloma: S1A), which was consistent with previous observations in lung adenocarcinoma and multiple myeloma cell lines.9, 15 Dose-dependent induction of apoptosis after JQ1 (Figure 1d,Supplementary Figure S1B) or OTX-015 (Supplementary Figure S1C) treatment was furthermore observed in sensitive DV90 and H1373 cells but not in resistant A549 and H460 cells irrespective of the p53 status of the cells.