c-Myb is a transcription factor that regulates hematopoiesis by controlling essential cellular processes, including proliferation, survival, and differentiation.1, 2 Dysregulated expression of c-myb has been implicated in the pathogenesis of leukemia, as in human T-cell leukemia (T-ALL) c-myb was found to be involved in translocation and duplication.3, 4 Dysregulation of c-myb also has roles in human colon and breast carcinoma.5, 6, 7 Additional studies demonstrate that overexpression or mutations in c-myb can release its oncogenic potential, especially in myeloid cells.8, 9. The gene discussed is MYB; the disease is leukemia.