It is recently reported that distal regulatory elements at −71 kb and −84 kb upstream of c-myb gene and binding of some erythroid TFs, including LDB1, GATA 1, TAL1, ETO 2, and KLF1, have been reported to be involved in regulation of c-myb expression in human erythroid progenitors, suggesting the involvement of distal regulation in human c-myb expression.38 It will be of interest to determine whether these distal regions are altered by mutation or other mechanism involving looping in human leukemias. Here, TAL1 is linked to leukemia.