KMT2A and acute myeloid leukemia: Following vehicle or tamoxifen treatment, animals bearing malignant AML were administered with either PBS or a chemotherapy regimen with cytarabine and doxorubicin, mimicking the treatment of patients at diagnosis presenting malignant AML.5 We observed that MLL-AF9-driven AML responded to chemotherapy, as both vehicle- and tamoxifen-treated mice receiving chemotherapy demonstrated prolonged survival compared with controls (Figure 5a).